---
title: Publications | Functional Fluidics
---

[![functionalfluidics_logo](https://www.functionalfluidics.com/hs-fs/hubfs/functionalfluidics_logo.jpg?width=132&name=functionalfluidics_logo.jpg)](https://www.functionalfluidics.com/)

- [About Us](https://www.functionalfluidics.com/about-us)
- [Services](https://www.functionalfluidics.com/services)
- [Assays](https://www.functionalfluidics.com/assays-2) 
    - [Flow Adhesion](https://www.functionalfluidics.com/assays/flow-adhesion)
    - [Mechanical Fragility](https://www.functionalfluidics.com/assays/mechanical-fragility)
    - [Dynamic Sickling Assay](https://www.functionalfluidics.com/assays-dynamicsicklingassay)
    - [Oxygenscan](https://www.functionalfluidics.com/assays/lorrca-oxygenscan)
    - [Osmoscan](https://www.functionalfluidics.com/assays-2/flow-adhesion-reverse-0)
- [Contract Research](https://www.functionalfluidics.com/contractresearch) 
    - [Nigeria Research Center](https://www.functionalfluidics.com/functional_fluidics_nigeria)
    - [RBC Test Menu](https://www.functionalfluidics.com/hubfs/Test%20Menu%20(2).pdf)
- Scientific Resources 
    - [Peer Reviewed Publications](https://www.functionalfluidics.com/scientificresources/peerreviewed)
    - [Abstracts](https://www.functionalfluidics.com/scientificresources/abstracts)
    - [ELIPSIS](https://www.functionalfluidics.com/scientificresources/elipsis)
- [News](https://www.functionalfluidics.com/news-and-presentations)

# Publications & Abstracts

 Peer Reviewed Articles

![](https://www.functionalfluidics.com/hubfs/Functional_Fluidics_Sept2018/Publications/white-down-arrow.png)

### Topics:

- [Invisible (62)](https://www.functionalfluidics.com/publications/tag/invisible)
- [Publications (17)](https://www.functionalfluidics.com/publications/tag/publications)
- [Adhesion (14)](https://www.functionalfluidics.com/publications/tag/adhesion)
- [Sickle Cell Disease (12)](https://www.functionalfluidics.com/publications/tag/sickle-cell-disease)
- [permanent (11)](https://www.functionalfluidics.com/publications/tag/permanent)
- [Flow Adhesion (10)](https://www.functionalfluidics.com/publications/tag/flow-adhesion)
- [Abstract (6)](https://www.functionalfluidics.com/publications/tag/abstract)
- [Presentations (5)](https://www.functionalfluidics.com/publications/tag/presentations)
- [Mechanical Fragility (4)](https://www.functionalfluidics.com/publications/tag/mechanical-fragility)
- [VLA-4 (4)](https://www.functionalfluidics.com/publications/tag/vla-4)
- [Dynamic Adhesion (3)](https://www.functionalfluidics.com/publications/tag/dynamic-adhesion)
- [News (3)](https://www.functionalfluidics.com/publications/tag/news)
- [HUVEC (2)](https://www.functionalfluidics.com/publications/tag/huvec)
- [Thrombosis (2)](https://www.functionalfluidics.com/publications/tag/thrombosis)
- [Flow Adhesion - P selectin (1)](https://www.functionalfluidics.com/publications/tag/flow-adhesion-p-selectin)
- [L-selectin (1)](https://www.functionalfluidics.com/publications/tag/l-selectin)

No publications were found.

<https://www.functionalfluidics.com/publications/functional-fluidics-proudly-announces-its-global-expansion-into-africa-in-the-fourth-quarter-of-2023>

Aug 16, 2023

[Functional Fluidics proudly announces its global expansion into Africa in the fourth quarter of 2023](https://www.functionalfluidics.com/publications/functional-fluidics-proudly-announces-its-global-expansion-into-africa-in-the-fourth-quarter-of-2023)

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Mar 18, 2021

[Cross-sectional analysis of adhesion in individuals with sickle cell disease using a standardized whole blood adhesion bioassay to VCAM-1](https://www.functionalfluidics.com/publications/cross-sectional-analysis-of-adhesion-in-individuals-with-sickle-cell-disease-using-a-standardized-whole-blood-adhesion-bioassay-to-vcam-1)

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Mar 18, 2021

[Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by Electronic Patient-Reported Outcomes, Actigraphy, and Biomarkers](https://www.functionalfluidics.com/publications/evaluation-of-longitudinal-pain-study-in-sickle-cell-disease-elipsis-by-electronic-patient-reported-outcomes-actigraphy-and-biomarkers)

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Mar 18, 2021

[Evaluation of Coagulation and Inflammatory Markers in Pediatric Patients on Extracorporeal Membrane Oxygenation (ECMO)](https://www.functionalfluidics.com/publications/evaluation-of-coagulation-and-inflammatory-markers-in-pediatric-patients-on-extracorporeal-membrane-oxygenation-ecmo)

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Mar 18, 2021

[Hemolytic Biomarkers Predict Adhesiveness of Sickle Blood Cells in a Clinical Adhesion Bioassay](https://www.functionalfluidics.com/publications/hemolytic-biomarkers-predict-adhesiveness-of-sickle-blood-cells-in-a-clinical-adhesion-bioassay)

- <http://www.facebook.com/sharer/sharer.php?u=https://www.functionalfluidics.com/publications/hemolytic-biomarkers-predict-adhesiveness-of-sickle-blood-cells-in-a-clinical-adhesion-bioassay>
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<https://www.functionalfluidics.com/publications/mechanical-fragility-as-a-potential-tine-independent-measure-of-membrane-integrity-among-stored-rbc-units>

Jan 13, 2021

[Mechanical Fragility as a Potential Time-Independent Measure of Membrane Integrity among Stored RBC Units](https://www.functionalfluidics.com/publications/mechanical-fragility-as-a-potential-tine-independent-measure-of-membrane-integrity-among-stored-rbc-units)

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<https://www.functionalfluidics.com/publications/impact-of-the-oscillating-bead-size-and-shape-on-induced-mechanical-fragility>

Sep 18, 2020

[Impact of the Oscillating Bead Size and Shape on Induced Mechanical Fragility](https://www.functionalfluidics.com/publications/impact-of-the-oscillating-bead-size-and-shape-on-induced-mechanical-fragility)

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<https://www.functionalfluidics.com/publications/rbc-mechanical-fragility-as-a-direct-blood-quality-metric>

Sep 18, 2020

[RBC Mechanical Fragility as a Direct Blood Quality Metric](https://www.functionalfluidics.com/publications/rbc-mechanical-fragility-as-a-direct-blood-quality-metric)

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<https://www.functionalfluidics.com/publications/progress-in-pediatric-cardiology-2019>

Sep 18, 2020

[Progress in Pediatric Cardiology 2019](https://www.functionalfluidics.com/publications/progress-in-pediatric-cardiology-2019)

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<https://www.functionalfluidics.com/publications/investigating-direct-non-age-metrics-of-stored-blood-quality-loss>

Sep 18, 2020

[Investigating Direct Non-Age Metrics of Stored Blood Quality Loss](https://www.functionalfluidics.com/publications/investigating-direct-non-age-metrics-of-stored-blood-quality-loss)

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<https://www.functionalfluidics.com/publications/individual-variability-in-response-to-a-single-sickling-event>

Sep 18, 2020

[Individual Variability in Response to a Single Sickling Event](https://www.functionalfluidics.com/publications/individual-variability-in-response-to-a-single-sickling-event)

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- [Abstract](https://www.functionalfluidics.com/publications/topic/abstract) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Nov 27, 2018

[A Longitudinal Study to Identify and Assess Adhesion Indices during Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease](https://www.functionalfluidics.com/publications/a-longitudinal-study-to-identify-and-assess-adhesion-indices-during-vaso-occlusive-crises-in-adults-and-adolescents-with-sickle-cell-disease-1)

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- [Abstract](https://www.functionalfluidics.com/publications/topic/abstract) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Nov 27, 2018

 Ke Liu, Xiufeng Gao, Jennell White, Michael U. Callaghan and Patrick C. Hines

[Longitudinal Evaluation of a Standardized P-Selectin Flow Adhesion Bioassay: Potential Role for the Assessment and Prediction of Vaso-Occlusive Episodes in Sickle Cell Disease](https://www.functionalfluidics.com/publications/longitudinal-evaluation-of-a-standardized-p-selectin-flow-adhesion-bioassay-potential-role-for-the-assessment-and-prediction-of-vaso-occlusive-episo-15433508)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

May 16, 2018

 British Journal of Haematology

[Sevuparin blocks sickle blood cell adhesion and sickle-leucocyte rolling on immobilized L-selectin in a dosedependent manner](https://www.functionalfluidics.com/publications/sevuparin-blocks-sickle-blood-cell-adhesion-and-sickle-leucocyte-rolling-on-immobilized-l-selectin-in-a-dosedependent-manner)

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<https://www.functionalfluidics.com/publications/sevuparin-blocks-sickle-blood-cell-adhesion-and-sickle-leukocyte-rolling-on-immobilized-l-selectin-in-a-dose-dependent-manner>

- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Nov 17, 2016

[Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner](https://www.functionalfluidics.com/publications/sevuparin-blocks-sickle-blood-cell-adhesion-and-sickle-leukocyte-rolling-on-immobilized-l-selectin-in-a-dose-dependent-manner)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Mechanical Fragility](https://www.functionalfluidics.com/publications/topic/mechanical-fragility)

Sep 16, 2016

[Impact of environment on Red Blood Cell ability to withstand mechanical stress](https://www.functionalfluidics.com/publications/impact-of-environment-on-red-blood-cell-ability-to-withstand-mechanical-stress)

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<https://www.functionalfluidics.com/publications/low-molecular-weight-heparin-inhibits-sickle-erythrocyte-adhesion-to-vcam-1-through-vla-4-blockade-in-a-standardized-microfluidic-flow-adhesion-assay>

- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Jun 24, 2016

[Low molecular weight heparin inhibits sickle erythrocyte adhesion to VCAM-1 through VLA-4 blockade in a standardized microfluidic flow adhesion assay](https://www.functionalfluidics.com/publications/low-molecular-weight-heparin-inhibits-sickle-erythrocyte-adhesion-to-vcam-1-through-vla-4-blockade-in-a-standardized-microfluidic-flow-adhesion-assay)

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<https://www.functionalfluidics.com/publications/vla-4-blockade-by-natalizumab-inhibits-sickle-reticulocyte-and-leucocyte-adhesion-during-simulated-blood-flow>

- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Jun 12, 2016

[VLA-4 blockade by natalizumab inhibits sickle reticulocyte and leukocyte adhesion during simulated blood flow.](https://www.functionalfluidics.com/publications/vla-4-blockade-by-natalizumab-inhibits-sickle-reticulocyte-and-leucocyte-adhesion-during-simulated-blood-flow)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Mechanical Fragility](https://www.functionalfluidics.com/publications/topic/mechanical-fragility)

May 16, 2016

[Differences in bead-milling-induced hemolysis of red blood cells due to shape and size of oscillating bead](https://www.functionalfluidics.com/publications/differences-in-bead-milling-induced-hemolysis-of-red-blood-cells-due-to-shape-and-size-of-oscillating-bead)

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<https://www.functionalfluidics.com/publications/evaluation-of-purified-poloxamer-188-vepoloxamer-on-sickle-red-blood-cell-rbc-membrane-function-properties>

- [Abstract](https://www.functionalfluidics.com/publications/topic/abstract) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Dec 6, 2015

[Evaluation of Purified Poloxamer-188 (vepoloxamer) on Sickle Red Blood Cell (RBC) Membrane Function Properties](https://www.functionalfluidics.com/publications/evaluation-of-purified-poloxamer-188-vepoloxamer-on-sickle-red-blood-cell-rbc-membrane-function-properties)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Dec 4, 2015

[TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1.](https://www.functionalfluidics.com/publications/tr2tr4-overexpression-in-a-humanized-sickle-cell-disease-mouse-model-decreases-rbc-adhesion-to-vcam-1)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Mechanical Fragility](https://www.functionalfluidics.com/publications/topic/mechanical-fragility)

Oct 22, 2015

[An approach to measuring RBC haemolysis and profiling RBC mechanical fragility](https://www.functionalfluidics.com/publications/an-approach-to-measuring-rbc-haemolysis-and-profiling-rbc-mechanical-fragility)

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<https://www.functionalfluidics.com/publications/increased-erythrocyte-adhesion-to-vcam-1-during-pulsatile-flow-application-of-a-microfluidic-flow-adhesion-bioassay>

- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Aug 26, 2015

[Increased erythrocyte adhesion to VCAM-1 during pulsatile flow: Application of a microfluidic flow adhesion bioassay.](https://www.functionalfluidics.com/publications/increased-erythrocyte-adhesion-to-vcam-1-during-pulsatile-flow-application-of-a-microfluidic-flow-adhesion-bioassay)

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<https://www.functionalfluidics.com/publications/pulsatile-flow-promotes-adhesion-in-sickle-cell-disease-clinical-application-of-a-microfluidic-bioassay>

- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Jun 24, 2015

[Pulsatile Flow Promotes Adhesion in Sickle Cell Disease: Clinical Application of a Microfluidic Bioassay.](https://www.functionalfluidics.com/publications/pulsatile-flow-promotes-adhesion-in-sickle-cell-disease-clinical-application-of-a-microfluidic-bioassay)

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- [Abstract](https://www.functionalfluidics.com/publications/topic/abstract) |
- [Sickle Cell Disease](https://www.functionalfluidics.com/publications/topic/sickle-cell-disease)

Sep 26, 2014

[Natalizumab Blocks Adhesion of Sickle Cell Whole Blood Cells to Activated Endothelial Cells under Flow Conditions.](https://www.functionalfluidics.com/publications/natalizumab-blocks-adhesion-of-sickle-cell-whole-blood-cells-to-activated-endothelial-cells-under-flow-conditions)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Mechanical Fragility](https://www.functionalfluidics.com/publications/topic/mechanical-fragility)

Aug 30, 2013

[Similar donors—similar blood?](https://www.functionalfluidics.com/publications/similar-donors-similar-blood-1)

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- [Abstract](https://www.functionalfluidics.com/publications/topic/abstract) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Dec 26, 2012

[VLA-4 blockade: A Novel Therapeutic Approach in Sickle Cell Disease.](https://www.functionalfluidics.com/publications/vla-4-blockade-a-novel-therapeutic-approach-in-sickle-cell-disease)

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- [Abstract](https://www.functionalfluidics.com/publications/topic/abstract) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Dec 26, 2012

[Application of Microfluidic Technology to Evaluate the Influence of Pulsatile Blood Flow on Adhesion of Pediatric Sickle Erytrhocytes.](https://www.functionalfluidics.com/publications/application-of-microfluidic-technology-to-evaluate-the-influence-of-pulsatile-blood-flow-on-adhesion-of-pediatric-sickle-erytrhocytes)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Sickle Cell Disease](https://www.functionalfluidics.com/publications/topic/sickle-cell-disease)

Sep 26, 2011

[Central Nervous System Events in Children with Sickle Cell Disease Presenting Acutely with Headache.](https://www.functionalfluidics.com/publications/central-nervous-system-events-in-children-with-sickle-cell-disease-presenting-acutely-with-headache)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications)

Jul 29, 2010

[Hematodiaphyseal Dysplasia: A Rare Cause Of A Myelophthisic Anemia.](https://www.functionalfluidics.com/publications/hematodiaphyseal-dysplasia-a-rare-cause-of-a-myelophthisic-anemia)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications)

Feb 1, 2008

[Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia.](https://www.functionalfluidics.com/publications/pulsed-dosing-with-oral-sodium-phenylbutyrate-increases-hemoglobin-f-in-a-patient-with-sickle-cell-anemia)

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<https://www.functionalfluidics.com/publications/novel-epinephrine-and-cyclic-amp-mediated-activation-of-b-camlu-dependent-sickle-ss-rbc-adhesion>

- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Apr 15, 2003

[Novel Epinephrine and Cyclic AMP-Mediated Activation of B-CAM/Lu-Dependent Sickle (SS) RBC Adhesion.](https://www.functionalfluidics.com/publications/novel-epinephrine-and-cyclic-amp-mediated-activation-of-b-camlu-dependent-sickle-ss-rbc-adhesion)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications)

Oct 15, 1998

[Sickle Cell Adhesion to Laminin: Potential Role for the alpha5 Chain.](https://www.functionalfluidics.com/publications/sickle-cell-adhesion-to-laminin-potential-role-for-the-5-chain)

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- [Publications](https://www.functionalfluidics.com/publications/topic/publications) |
- [Adhesion](https://www.functionalfluidics.com/publications/topic/adhesion)

Sep 1, 1997

[Identification of a Region of Laminin That Adheres to Red Blood Cells of Sickle Cell Anemia Patients.](https://www.functionalfluidics.com/publications/identification-of-a-region-of-laminin-that-adheres-to-red-blood-cells-of-sickle-cell-anemia-patients)

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