--- title: Red blood cell biomarkers may predict sickle cell disease (SCD) severity and the risk of vaso-occlusive crisis, according to a study that evaluated the FA-WB-VCAM blood test. description: Red blood cell biomarkers may predict sickle cell disease (SCD) severity and the risk of vaso-occlusive crisis, according to a study that evaluated the FA-WB-VCAM blood test. image: https://www.functionalfluidics.com/hubfs/Untitled%20design%20%282%29-2.png --- [![functionalfluidics\_logo](https://www.functionalfluidics.com/hs-fs/hubfs/functionalfluidics_logo.jpg?width=132&name=functionalfluidics_logo.jpg)](https://www.functionalfluidics.com/) - [About Us](https://www.functionalfluidics.com/about-us) - [Services](https://www.functionalfluidics.com/services) - [Assays](https://www.functionalfluidics.com/assays-2) - [Flow Adhesion](https://www.functionalfluidics.com/assays/flow-adhesion) - [Mechanical Fragility](https://www.functionalfluidics.com/assays/mechanical-fragility) - [Dynamic Sickling Assay](https://www.functionalfluidics.com/assays-dynamicsicklingassay) - [Oxygenscan](https://www.functionalfluidics.com/assays/lorrca-oxygenscan) - [Osmoscan](https://www.functionalfluidics.com/assays-2/flow-adhesion-reverse-0) - [Contract Research](https://www.functionalfluidics.com/contractresearch) - [Nigeria Research Center](https://www.functionalfluidics.com/functional_fluidics_nigeria) - [RBC Test Menu](https://www.functionalfluidics.com/hubfs/Test%20Menu%20(2).pdf) - Scientific Resources - [Peer Reviewed Publications](https://www.functionalfluidics.com/scientificresources/peerreviewed) - [Abstracts](https://www.functionalfluidics.com/scientificresources/abstracts) - [ELIPSIS](https://www.functionalfluidics.com/scientificresources/elipsis) - [News](https://www.functionalfluidics.com/news-and-presentations) [\< Go Back To News & Media](https://www-functionalfluidics-com.sandbox.hs-sites.com/news-and-presentations/) ## Red blood cell biomarkers may predict sickle cell disease (SCD) severity and the risk of vaso-occlusive crisis, according to a study that evaluated the FA-WB-VCAM blood test. Red blood cell biomarkers may predict sickle cell disease (SCD) severity and the risk of vaso-occlusive crisis, according to a study that evaluated the FA-WB-VCAM blood test. - - - April 1, 2022 0% read Subscribe to our Newsletter ![Untitled design (2)-2](https://www.functionalfluidics.com/hs-fs/hubfs/Untitled%20design%20(2)-2.png?width=485&name=Untitled%20design%20(2)-2.png) Red blood cell biomarkers may predict sickle cell disease (SCD) severity and the risk of vaso-occlusive crisis, according to a study that evaluated the FA-WB-VCAM blood test. “Our latest research indicates that one of our clinically available red blood cell health tests called Flow Adhesion of Whole Blood to VCAM (FA-WB-VCAM) may be a plausible surrogate endpoint for SCD severity,” Patrick Hines, MD, PhD, CEO and founder of Functional Fluidics, the company that developed the test, said in a press release. The study, “Longitudinal assessment of adhesion to vascular cell adhesion molecule-1 at steady state and during vaso-occlusive crises in sickle cell disease,” was published in the British Journal of Haematology. A vaso-occlusive crisis (VOC) occurs when sickle-shaped red blood cells stick to blood vessel walls and block blood flow, depriving tissues of oxygen. As a result, VOCs can cause severe pain and organ damage. But there is a lack of reliable biomarkers that can predict VOC risk and severity — and that could potentially identify SCD patients at risk of VOC complications in the early stages of the disease. Such early identification with cell biomarkers could help prevent organ damage.   Read More: [https://sicklecellanemianews.com/2022/02/24/red-blood-cell-biomarkers-predict-scd-severity-crisis-risk/](https://sicklecellanemianews.com/2022/02/24/red-blood-cell-biomarkers-predict-scd-severity-crisis-risk/)     Subscribe to our Newsletter Subscribe to our Newsletter ### ### Recommended Reads ![](https://www.functionalfluidics.com/hubfs/Screenshot%202025-12-01%20105529.png) Dec 1, 2025 #### [Functional Fluidics Welcomes Biopharma Leader Bert Bruce as Senior Advisor](https://www.functionalfluidics.com/publications/functional-fluidics-welcomes-biopharma-leader-bert-bruce-as-senior-advisor) ![](https://www.functionalfluidics.com/hubfs/Screenshot%202025-11-30%20195918.png) Dec 1, 2025 #### [Functional Fluidics to Present New Sickle Cell Disease Data at the 2025 ASH Annual Meeting in Orlando, Florida](https://www.functionalfluidics.com/publications/functional-fluidics-to-present-new-sickle-cell-disease-data-at-the-2025-ash-annual-meeting-in-orlando-florida) ### Contact Us   # **Our Location** 440 Burroughs Street, Suite 447, Detroit, MI 48202 United States Email: [info@functionalfluidics.com](mailto:info@functionalfluidics.com) Phone:313-315-2555 ### Subscribe to Our Newsletter - [Services](https://www.functionalfluidics.com/services) - [Assays](https://www.functionalfluidics.com/assays-2) - [RBC Test Menu](https://www.functionalfluidics.com/hubfs/Test%20Menu%20(2).pdf) - [Publications](https://www.functionalfluidics.com/publications/tag/publications) © Copyright Functional Fluidics 2016.